Has your RIP (Raster Image Processor) server recently slowed to a crawl? RIPs typically manage multiple printers and users creating a lot of file traffic. Depending on the way the RIP is configured, the hard drive of the RIP server can fill up with old jobs, previews, and temporary files causing noticeable sluggishness.
The good news is that most RIPs have some option for cleaning out old files, either as a manually initiated clean up, or as an automated scheduled action. If the RIP does not offer this option it is a good idea to shut the RIP down periodically and manually clean out hot folders and temporary folders(consult Spectraflow for help).
The file system should also be maintained from time to time, using the disk utility on OS-X systems or the disk defragmenter on Windows boxes.
Making a backup of important custom files such as ICC profiles and linearizations is a very good idea as well.